Sensory signal transduction, synaptic communication and plasticity, visual system, neurovascular coupling, vestibulo-ocular reflex, pain systems, muscle & muscle spindles.
Position of the Course
This course aims at providing knowledge, understanding and insight into the field of fundamental and clinical neurophysiology based on a selection of neuroscience topics where important new findings have emerged over the past 10 years. The approach is directed towards the molecular, cellular, electrophysiological and systems levels, and includes methodological and technical research considerations.
Update on sensory signal transduction
The visual system from retina to the visual cortical areas
Update on excitatory and inhibitory postsynaptic receptors, downstream
signaling and prototypic examples of connection systems
Synaptic communication and role of glial cells
Neurovascular coupling, neurometabolic coupling and neurobarrier
Synaptic plasticity, long-term potentiation (LTP) and long-term
The vestibulo-ocular reflex and the optokinetic nystagmus
Painsystems and mechanisms of chronic pain
Control of muscle length and contraction, hyperreflexivity and clonus
Examples of methodological and instrumentation approaches for
experimental and clinical research
Having successfully completed the courses General biochemistry, Biochemistry II, Molecular biology I, Molecular biology II, General physiology, Physiology of the organ systems and Human pathogenesis from the bachelor program biomedical sciences, or having acquired the relevant ending objectives by other means.
Teaching and Learning Material
Being able to explain taste, olfaction, hearing and visual sensory
signal transduction and point to new insights in this field.
To have knowledge of the connections, organization and functional
division of the visual system from retina to visual cortex.
Being able to give an overview of the different postsynaptic receptor
classes and explain the relation between molecular and
electrophysiological data and synaptic functioning.
To have knowledge of the prototypic neurotransmitter connection
systems in the brain and spinal cordBeing able to sum-up and explain
disturbances of neurotransmitter systems in prototypic examples of
To have knowledge of glial cell functions and explain their role in
neural tissue functioningBeing able to explain the principles of
neurovascular coupling, neurometabolic coupling and neurobarrier
coupling, and clarify the mechanisms behind these coupling phenomena.
Being able to define synaptic plasticity terms like adaptation,
sensitization, LTP, LTD, co-incidence detection and explain their
Being able to clarify the contribution of LTD in the adaptations of
the vestibulo-ocular reflex.
To have knowledge on the signal transduction of pain sensation from
the pain afferents to the cortical areas, and being able to explain
possible underlying mechanisms of the development of chronic pain.
Being able to sketch the feedback circuit of muscle and muscle
spindles, and explain the modifications that bring about
hyperreflexivity and clonus
To have knowledge on key learning material (books) in the neuroscience
field and being able to use primary and secondary source material to
solve or document focused questions related to neuroscience.
The learning material consists of references to capita selecta from handbooks, original and review publications and websites (in english). The necessary references to the learning material are communicated via the Minerva learning platform.
Course Content-Related Study Coaching
- - Duane E. Haines, Fundamental Neuroscience, Churchill Livingstone, recentste editie
- - Squire et al., Fundamental Neuroscience, Academic Press, recentste editie
- - Kandel et al., Principles of Neural Science, McGraw-Hill, recentste editie
- - Siegel et al., Basic Neurochemistry, Lippincott-Raven, recentste editie
Evaluation during examination period